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Using the following two case-studies independently:

Construct and test the following protocol:

  • Review each case-study
  • Choose appropriate dichotomous, polytomous, or continuous outcome variables, e.g., use ALSFRS_slope for ALS, CHRONICDISEASESCORE for case 06 and cast as an outcome dichotomous outcome
  • Apply appropriate data preprocessing
  • Perform regression modeling for continuous outcomes
  • Perform classification and prediction using various methods (LDA, QDA, AdaBoost, SVM, Neural Network, KNN) for discrete outcomes
  • Apply cross-validation on these regression and classification methods, respectively
  • Report standard error for regression approaches
  • Report appropriate quality metrics that can be used to rank the forecasting approaches based on the predictive power of the corresponding prediction/classification results
  • Compare the results of model-driven and data-driven (e.g., KNN) methods
  • Compare sensitivity and specificity, respectively
  • Use unsupervised clustering methods (e.g., k-Means) and spectral clustering
  • Evaluate and justify k-Means model and detect how agreement of the clusters with labels
  • Report the classification error of k-means and compare it against the result of k-means++.

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